cAMP/Ca2+ 通路發(fā)現(xiàn)者PCR芯片 cAMP/Ca2+ PathwayFinder PCR
cAMP/Ca2+ 通路發(fā)現(xiàn)者PCR芯片 cAMP/Ca2+ PathwayFinder PCR
cAMP/Ca2+ 通路發(fā)現(xiàn)者PCR芯片cAMP/Ca2+ PathwayFinder PCR Array
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| 地區(qū)： | 上海 |
| 簡(jiǎn)介： | 上海 |
| 提供商： | SABio |
| 服務(wù)名稱： | PCR芯片 |
芯片可用于研究參與cAMP/Ca2+應(yīng)答的84的關(guān)鍵基因的表達(dá)。這一芯片所包含的基因，其啟動(dòng)子區(qū)域具有SRE或SRE-like增強(qiáng)子序列、CRE增強(qiáng)子序列或其他Ca2+應(yīng)答元素。通過(guò)實(shí)時(shí)定量PCR的方法，研究者即能夠利用該芯片簡(jiǎn)單可靠地同時(shí)檢測(cè)cAMP/Ca2+信號(hào)通路相關(guān)基因的表達(dá)。 Genes whose promoters contain SRE or SRE-like enhancer sequences: CNN1 (calponin), CYR61, EGR1, EGR2, FOS, FOSB, HSPA4 (hsp70), JUNB, NR4A2 (Nur77), S100A6 (Calcyclin), SCG2 (secretogranin II), SRF, THBS1 (TSP-1), VCL. Genes whose promoters contain the CRE enhancer sequence: Neuropeptides / Neurotransmitters: ADRB1 (b1 adrenergic receptor), CGA (Chorionic gonadotropin A), CHGA (Chromogranin), GCG (Glucagon), GIPR, INHBA (Inhibin A), KCNA5 (KV1.5), NOS2 (Inducible nitric oxide synthase), PENK (Enkephalin), PRL, S100A12 (CGRP), S100G, SCG2, SLC18A1 (Vesicular monoamine transporter), SST (Somatostatin), SSTR2 (Somatostatin receptor 2), TACR1 (Substance P receptor), TH(Tyrosine hydroxylase), VIP. Cell Cycle / Cell Survival / DNA Repair: BCL2, BRCA1, CCNA1 (CyclinA), CCND1 (CyclinD1), CDK5, CDKN2B (p15IND4b), GEM, NF1, PCNA, PMAIP1 (NoxA), PPP1R15A (GADD34), RB1. Growth Factor: AREG (Amphiregulin), BDNF, CTF1 (Cardiotrophin), FGF6, TGFB3, TNF. Signaling: DUSP1 (Ptpn16), HSPA5 (Grp78), PLN (Phospholamban), PPP2CA (Protein phosphatase 2A alpha), PRKAR1A (Proteinkinase A regulatory subunit), SGK1. Transcription: ATF3, CREB1, CREM, EGR1, EGR2, FOS, JUND, MAF, NR4A2 (Nur77), PER1, POU1F1 (Pit-1), POU2AF1 (OCA-B), STAT3. Metabolism: AHR, AMD1, ENO2, HK2, LDHA, PCK2, SOD2. Immune Regulation: IL2, IL6, MIF, PTGS2 (Cox-2). Genes whose promoters contain other Ca2+ responsive elements: CALB1 (calbindin 1), CALB2 (calbindin 2), CALM1 (Calmodulin 1), CALR (Calreticulin), DDIT3 (GADD153), NCAM1, NPY, PLAT (tPA). |
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