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Brain Cancer miScript miRNA PCR Array
人腦癌癥miRNAPCR芯片The Human Brain Cancer miScript miRNA PCR Array profiles the expression of 84 miRNAs known to alter their expression during nervous system-related carcinogenesis. This array provides cancer researchers with a convenient way to quickly analyze the miRNAs most relevant to brain and central nervous system tumorigenesis. Brain tumors, which cause uncontrolled cellular growth in the cranium or spinal column, involve any of the cell types found in the brain, such as neurons, glial cells, astrocytes, or cells of the meninges.By attenuating gene expression, miRNAs regulate many biological functions, and some, such as those in the miR-17-92 cluster, have known oncogenic properties. Expression studies of different brain tumor types have identified dysregulated miRNA; however, few are functionally linked to pathogenic mechanisms. Research into the functional consequences of miRNA dysregulation during neurocarcinogenesis may yield insights into the molecular mechanisms behind the pathogenesis of brain tumors.The array contains miRNAs with known functional consequences as well as miRNAs with a significant dysregulation but unknown function during oncogenesis. The profiling results from this array may yield insights into the molecular mechanisms behind the pathogenesis of multiple nervous system cancers. A set of controls present on this array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs related to brain cancer can be easily and reliably analyzed with this miScript miRNA PCR Array.
miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease.
96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.
人大腦癌癥miRNAPCR芯片用于分析在神經(jīng)系統(tǒng)相關(guān)的致癌作用中發(fā)生表達(dá)變異的84 個(gè)miRNA的表達(dá)。這個(gè)芯片為癌癥研究人員提供了一個(gè)方便的方法來快速分析大腦和中樞神經(jīng)系統(tǒng)腫瘤發(fā)生最相關(guān)的miRNA。腦部腫瘤,導(dǎo)致頭蓋骨和脊柱的細(xì)胞增長(zhǎng)不受控制，涉及任大腦中發(fā)現(xiàn)的何細(xì)胞類型，如神經(jīng)元、神經(jīng)膠質(zhì)細(xì)胞、星形膠質(zhì)細(xì)胞或細(xì)胞腦膜。通過衰減基因表達(dá)，miRNA調(diào)節(jié)許多生物功能和一些比如在miR-17-92 cluster中已知的致癌特性。不同的腦部腫瘤類型的表達(dá)研究已經(jīng)發(fā)現(xiàn)了miRNA表達(dá)的異常，然而其功能與致病機(jī)制了解很少。這個(gè)芯片包含功能已知的及在腫瘤形成中嚴(yán)重失調(diào)但功能未知的miRNA。這個(gè)芯片的分析結(jié)果可能在多種神經(jīng)系統(tǒng)癌癥背后的發(fā)病機(jī)理產(chǎn)生更深入的了解。每張芯片含一個(gè)對(duì)照組使得分析數(shù)據(jù)時(shí)可以用相對(duì)定量ΔΔCT方法評(píng)估逆轉(zhuǎn)錄效率,基因組DNA污染,和PCR效率。利用這張芯片，通過實(shí)時(shí)定量PCR，可以簡(jiǎn)易且可靠地分析大腦癌癥關(guān)鍵基因集的表達(dá)。
miScript miRNA PCR芯片僅用于分子生物學(xué)應(yīng)用。本產(chǎn)品不用于疾病的診斷、預(yù)防和治療。
提供96孔板——384 -(4 x 96)板,和100孔板
Anaplastic Astrocytoma:miR-107, miR-10b-5p, miR-124-3p, miR-125b-5p, miR-127-5p, miR-129-5p, miR-137, miR-138-5p, miR-187-3p, miR-203a, miR-218-5p, miR-296-5p, miR-31-5p, miR-320a, miR-7-5p.
Glioblastoma:miR-101-3p, miR-107, miR-10b-5p, miR-124-3p, miR-128, miR-129-5p, miR-130a-3p, miR-132-3p, miR-133a, miR-133b, miR-137, miR-138-5p, miR-149-5p, miR-153, miR-16-5p, miR-181a-5p, miR-181b-5p, miR-185-5p, miR-187-3p, miR-191-5p, miR-203a, miR-21-5p, miR-210, miR-218-5p, miR-221-3p, miR-222-3p, miR-222-5p, miR-23a-3p, miR-23b-3p, miR-25-3p, miR-29b-3p, miR-31-5p, miR-323a-5p, miR-328, miR-34a-5p, miR-425-5p, miR-451a, miR-486-5p, miR-7-5p.
Glioma:miR-106b-5p, miR-10b-5p, miR-128, miR-130b-3p, miR-144-3p, miR-146b-5p, miR-148a-3p, miR-15a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-181a-5p, miR-181b-5p, miR-182-5p, miR-183-5p, miR-184, miR-19a-3p, miR-200a-3p, miR-20a-5p, miR-21-5p, miR-210, miR-221-3p, miR-222-3p, miR-23a-3p, miR-25-3p, miR-26a-5p, miR-27a-3p, miR-296-5p, miR-328, miR-34a-5p, miR-451a, miR-486-5p, miR-9-5p, miR-9-3p, miR-93-5p.
Medulloblastoma:miR-106b-5p, miR-124-3p, miR-125a-5p, miR-125b-5p, miR-127-5p, miR-128, miR-129-5p, miR-130a-3p, miR-130b-3p, miR-133b, miR-137, miR-138-5p, miR-148a-3p, miR-150-5p, miR-153, miR-17-92 cluster (miR-17-5p, miR-18a-5p, miR-19a-3p, miR-20a-5p, miR-19b-3p, miR-92a-3p), miR-17-3p, miR-187-3p, miR-190a, miR-191-5p, miR-203a, miR-210, miR-216a-5p, miR-217, miR-218-5p, miR-25-3p, miR-29a-3p, miR-29b-3p, miR-30b-5p, miR-30c-5p, miR-320a, miR-323a-5p, miR-324-5p, miR-326, miR-328, miR-331-5p, miR-335-5p, miR-34a-5p, miR-425-5p, miR-7-5p, miR-9-3p, miR-93-5p, miR-96-5p.
Meningioma:let-7b-5p, miR-106a-5p, miR-106b-5p, miR-125a-5p, miR-153, miR-15a-5p, miR-181a-5p, miR-185-5p, miR-19b-3p, miR-200a-3p, miR-217, miR-23b-3p, miR-26a-5p, miR-27a-3p, miR-29a-3p, miR-335-5p, miR-451a.
Neuroblastoma:let-7b-5p, miR-106a-5p, miR-107, miR-125a-5p, miR-125b-5p, miR-128, miR-129-5p, miR-137, miR-141-3p, miR-146a-5p, miR-149-5p, miR-150-5p, miR-17-3p, miR-181a-5p, miR-181b-5p, miR-184, miR-187-3p, miR-190a, miR-200a-3p, miR-216a-5p, miR-221-3p, miR-23b-3p, miR-24-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30b-5p, miR-30c-5p, miR-320a, miR-323a-5p, miR-324-5p, miR-326, miR-331-5p, miR-335-5p, miR-34a-5p, miR-9-5p, miR-92a-3p, miR-93-5p.
Retinoblastoma:miR-320a
工作原理：
What miScript miRNA PCR Arrays offer?
Guaranteed Performance* - ready-to-use for gene expression analysis
Time & Cost Saving - less than 30 min hands-on time to analyze 84 or 372 miRNA
Simple Data Analysis - easy-to-use Excel-Based Data Analysis Template |
